The aim of present investigation is to formulate the mouth dispersible film of Desloratadine by solvent casting technique. The Desloratadine is class of antihistaminic drug which does not cross blood brain barriers like other first generation antihistaminic. Drug shows hepatic first pass metabolism hence there is need to develop fast dispersible film. The film prepared by solvent casting technique and evaluated for their mechanical properties. The thickness of film lies between 0.05 to 0.07mm. The weight of all factorial batches observed between 31.15 to 35.60 mg with standard deviation less than 0.2%. The folding endurance of all batches observed between 90.33to135 .For the batches F4, F7, F9 the folding endurance observed 124,131.33,135 respectively. The in vitro disintegration time for all batches measured between 9.6 to 15.3 seconds. The percent drug content observed between 97.85 to 99.16 %. In case of F4 and F6 formulations about 99.25% and 97.38% of drug was released at 2min which shows faster drug release.
Loading....